Interleukin-27 alpha (IPR026207)

Short name: IL-27_alpha

Overlapping homologous superfamilies


Family relationships



This entry represents IL27-A proteins (known as IL-30/IL27-p28). Interleukin-27 is a heterodimeric cytokine composed of two subunits; IL27-A (IL27-p28) and Epstein-Barr virus-induced gene 3 (EBI3, also known as IL-27B) [PMID: 12121660].

IL27 is a cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells [PMID: 17294231]. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivation [PMID: 17068156, PMID: 18191724].

GO terms

Biological Process

GO:0042129 regulation of T cell proliferation

Molecular Function

GO:0045523 interleukin-27 receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.