Intracellular hyaluronic acid binding protein (IPR026203)

Short name: IHABP

Overlapping homologous superfamilies


Family relationships



The extracellular matrix component hyaluronan plays important roles in various processes of organogenesis, cell migration and cancer [PMID: 9601097]. Recognition of and binding to hyaluronan is mediated by cell surface receptors.

The proteins in this family were initially called receptor for hyaluronan mediated motility (RHAMM), and were thought to be involved in cell motility [PMID: 1380898]. However, several lines of evidence suggest that they do not function as a conventional motility receptors for hyaluronan, leading to the suggestion they should be renamed intracellular hyaluronic acid binding protein (IHABP) [PMID: 9601097, PMID: 9601098].

IHABP is overexpressed in many cancers and may be involved in cellular transformation and metastasis formation [PMID: 21940500], and in regulating extracellular-regulated kinase (ERK) activity [PMID: 9556628].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005540 hyaluronic acid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.