TYRO protein tyrosine kinase-binding protein (IPR026200)

Short name: Tyrobp

Overlapping homologous superfamilies


Family relationships



TYRO protein tyrosine kinase-binding protein (Tyrobp), also called DNAX-activation protein 12 (DAP12), is expressed by NK cells and myeloid cells and mediates signalling for numerous cell-surface receptors expressed by these cells. It has been shown to both potentiate and attenuate the activation of these cells [PMID: 17220916, PMID: 17100880]. More than 20 receptor chains have been shown to associate with DAP12. It is involved for instance in neutrophil activation mediated by integrin [PMID: 17086186].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.