Syntaphilin (IPR026196)

Short name: Syntaphilin

Overlapping homologous superfamilies


Family relationships


Syntaphilin is selectively expressed in the brain. It competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1. In this way, syntaphilin may function as a molecular clamp, controlling free syntaxin-1 availability for the assembly of the SNARE complex, thereby regulating synaptic vesicle exocytosis [PMID: 10707983].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017075 syntaxin-1 binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.