Anaphase-promoting complex subunit 15 (IPR026182)

Short name: ANAPC15

Overlapping homologous superfamilies


Family relationships



Human ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C; it is not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It also required for degradation of CDC20 [PMID: 21926987].

GO terms

Biological Process

GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005680 anaphase-promoting complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.