SLAIN motif-containing protein (IPR026179)

Short name: Slain

Overlapping homologous superfamilies


Family relationships



This family consists of SLAIN motif-containing proteins, including SLAIN1 and SLAIN2. SLAIN1 was named after the SLAIN amino acid stretch in its C terminus. It is expressed at the stem cell and epiblast stages of ESC differentiation and in the epiblast, nervous system, tailbud and somites of the developing embryo in mice [PMID: 16546155]. SLAIN2 has been shown to bind to the plus end of microtubules and to regulate microtubule dynamics and organisation. It promotes cytoplasmic microtubule nucleation and elongation. It is required for normal structure of the microtubule cytoskeleton during interphase [PMID: 21646404].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.