Mitochondria-eating protein (IPR026169)

Short name: MIEAP

Overlapping homologous superfamilies


Family relationships



Mitochondria-eating protein (MIEAP, also known as spermatogenesis-associated protein 18), a p53-inducible protein, is a key regulator of mitochondrial quality that mediates the repair or degradation of unhealthy mitochondria in response to mitochondrial damage [PMID: 21264221]. It induces intra-mitochondrial lysosome-like organella that eliminate oxidised mitochondrial proteins without destroying the mitochondrial structure, leading to improvement in mitochondrial function [PMID: 21264221]. It is also involved in degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade the mitochondria by accumulating lysosomes [PMID: 21264228].

GO terms

Biological Process

GO:0033554 cellular response to stress

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005741 mitochondrial outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.