Family

Cytoskeleton-associated protein 2 family (IPR026165)

Short name: CKAP2_fam

Family relationships

None.

Description

The cytoskeleton-associated protein 2 (CKAP2) family includes CKAP2 and CKAP2-like proteins. Mouse CKAP2 has been shown to possess microtubule stabilising properties [PMID: 15504249] and is involved in regulating aneuploidy, cell cycle, and cell death in a p53-dependent manner [PMID: 16061649]. In human, CKAMP2 is up-regulated in primary gastric cancers [PMID: 12942315]. It has been shown that human CKAP2 is degraded by APC/C-Cdh1 during mitotic exit and that a tight regulation of CKAP2 protein level is important for mitotic progression [PMID: 17376772].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER