Family

FAM178 family (IPR026161)

Short name: FAM178

Family relationships

None.

Description

This entry represents the FAM178 family, whose members are metazoan proteins and include FAM178A and FAM178B. The human FAM178A protein has been shown to be widely expressed [PMID: 12459258] and is phosphorylated upon DNA damage, probably by ATM (ataxia telangiectasia mutated) or ATR (ATM and Rad3-related) [PMID: 17081983, PMID: 17525332].

FAM178A, also known as SLF2 (SMC5-SMC6 complex localization factor 2), forms a complex with RAD18 and SLF1, and together they define a pathway that suppresses genome instability by recruiting the SMC5/6 cohesion complex to DNA lesions [PMID: 25931565].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER