Resistance to inhibitors of cholinesterase protein 3 (IPR026160)

Short name: Ric3

Overlapping homologous superfamilies


Family relationships



Human Ric3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. It may also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4 [PMID: 12821669, PMID: 15504725, PMID: 15809299, PMID: 15927954, PMID: 16120769, PMID: 17609200].

C. elegans Ric3 is required for maturation and cell surface expression of acetylcholine receptors [PMID: 11867529, PMID: 15932871, PMID: 16466809].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.