Family

Apolipoprotein B receptor (IPR026158)

Short name: ApolipoprotB_rcpt

Family relationships

None.

Description

Apolipoprotein B receptor (also known as apolipoprotein B-100 receptor) is a macrophage receptor that binds to apolipoprotein (apo) B48 of dietary triglyceride (TG)-rich lipoproteins, or to an apoB100-like domain in hypertriglyceridemic very low-density lipoproteins [PMID: 10852956]. The receptor has been shown to be capable of binding and internalising triglyceride-rich lipoproteins, even in the absence of other macrophage-specific proteins, such as apoE or lipoprotein lipase, that can enhance macrophage uptake of lipoproteins [PMID: 10852956]. Apolipoprotein B receptor may be involved in provision of essential lipids to reticuloendothelial cells. It also has a role in remnant lipoprotein-induced macrophage foam cell formation, and thus may be involved in atherosclerosis [PMID: 15591219].

GO terms

Biological Process

GO:0006869 lipid transport

Molecular Function

GO:0030228 lipoprotein particle receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER