Apelin (IPR026155)

Short name: Apelin

Overlapping homologous superfamilies


Family relationships



Apelin is a bioactive peptide with a wide variety of physiological actions, which are mediated by its interaction with its specific G protein-coupled receptor, APJ [PMID: 9792798]. The protein is cleaved into several different active forms, including apelin-36, apelin-17 and apelin-13. Apelin has been shown to be involved in the regulation of cardiovascular and fluid homeostasis, food intake, cell proliferation, and angiogenesis [PMID: 21725702]. It has also been shown to inhibit human immunodeficiency virus type 1 entry into cells coexpressing CD4 and APJ [PMID: 11090199].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0031704 apelin receptor binding
GO:0005179 hormone activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.