Treslin (IPR026153)

Short name: Treslin

Overlapping homologous superfamilies


Family relationships



Treslin, a TopBP1-interacting protein, is necessary for DNA replication in vertebrates [PMID: 21646402]. Prior to the initiation of DNA replication, treslin associates with TopBP1 in a Cdk2-dependent manner [PMID: 20116089]. The proteins then collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins [PMID: 20116089]. Treslin is also an important checkpoint regulator, and is required to prevent mitotic entry after treatment with ionizing radiation [PMID: 20080954].

GO terms

Biological Process

GO:0006260 DNA replication
GO:0033314 mitotic DNA replication checkpoint
GO:0010212 response to ionizing radiation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.