Mitochondrial antiviral-signalling protein (IPR026148)

Short name: Mt_antiviral_sig_pro

Overlapping homologous superfamilies


Family relationships



Human mitochondrial antiviral-signalling protein is required for innate immune defence against viruses. It acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). It may activate the same pathways following detection of extracellular dsRNA by TLR3. It also may protect cells from apoptosis [PMID: 16125763, PMID: 16153868, PMID: 16177806, PMID: 16127453, PMID: 19631370].

GO terms

Biological Process

GO:0051607 defense response to virus

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.