Neurosecretory protein VGF (IPR026128)

Short name: VGF

Overlapping homologous superfamilies


Family relationships



VGF protein is a neurosecretory protein originally identified as a product of the nerve growth factor responsive gene Vgf in rat pheochromocytoma PC12 cells [PMID: 2676516, PMID: 3839317]. VGF may be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system [PMID: 19194657].

Neuroendocrine regulatory peptides (NERP)-1 and NERP-2 are bioactive peptides processed from VGF and involved in the control of body fluid homeostasis by regulating vasopressin release. Administration of NERPs suppresses hypertonic saline- or angiotensin II-induced vasopressin release from the hypothalamus and pituitary [PMID: 19194657].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005184 neuropeptide hormone activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.