Family

Amnionless (IPR026112)

Short name: AMN

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Human amnionless (AMN) is necessary for efficient absorption of vitamin B12. Defects in AMN is a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1), also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS)[PMID: 14576052].

AMN may direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm [PMID: 11279523, PMID: 9851841].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER