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Overview
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Structures
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Cross-references
Family
Amnionless (IPR026112)
Short name: AMN
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
Human amnionless (AMN) is necessary for efficient absorption of vitamin B12. Defects in AMN is a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1), also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS)[PMID: 14576052].
AMN may direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm [PMID: 11279523, PMID: 9851841].