G kinase-anchoring protein 1 (IPR026109)

Short name: GKAP1

Overlapping homologous superfamilies


Family relationships



GKAP1 is also called GKAP42. cGMP-dependent protein kinase (cGK) is a major cellular receptor of cGMP, playing important roles in cGMP-dependent signal transduction pathways [PMID: 10671526]. Using the yeast two-hybrid system with cGK-Ialpha as a bait, a male germ- cell-specific 42 kDa protein, GKAP42 (42 kDa cGMP-dependent protein kinase anchoring protein) has been identified [PMID: 10671526].

The N-terminal 66 amino acids of cGK-Ialpha were shown to be sufficient for association with GKAP42, but GKAP42 did not interact with cGK-Ibeta, cGK-II or cAMP-dependent protein kinase [PMID: 10671526]. GKAP42 mRNA is specifically expressed in testis, where it is restricted to spermatocytes and early-round spermatids [PMID: 10671526]. GKAP42 is believed to function as an anchoring protein for cGK-Ialpha, and it is thought that cGK-Ialpha may participate in germ-cell development through phosphorylation of Golgi-associated proteins such as GKAP42 [PMID: 10671526].

A recurring chromosomal aberration in acute myeloid leukemia (AML) is deletion of the long arm of chromosome 9, del(9q) [PMID: 16015647]. The Commonly Deleted Region (CDR) has been defined to less than 2.4 Mb, and found to contain 7 known genes, including GKAP42. The results of mutation and expression analyses of these genes are consistent with a model of tumour suppression mediated by haploinsufficiency of critical genes in del(9q) AML.

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005794 Golgi apparatus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.