Hyaluronan synthase 3 (IPR026108)

Short name: HA_synthase_3

Overlapping homologous superfamilies


Family relationships



Hyaluronan synthase 3 plays a role in hyaluronan/hyaluronic acid (HA) synthesis [PMID: 9083017].

There are three different, but related hyaluronan synthases - HAS1, HAS2 and HAS3. They are multipass transmembrane enzymes, the active sites of which protrude from the inner face of the plasma membrane. HA is an unbranched disaccharide glucuronic acid/N-acetylglucosamine polymer and is one of the main components of the extracellular matrix [PMID: 15229478]. High level of HA in humans is associated with cancer progression [PMID: 15229478, PMID: 11313172]. In vertebrates, different HA polymer length can trigger different biological responses. High-molecular-mass HA represses mitogenic signalling and has anti-inflammatory properties, while low-molecular-mass HA promotes proliferation and inflammation [PMID: 17296798, PMID: 23783513].

GO terms

Biological Process

GO:0030213 hyaluronan biosynthetic process

Molecular Function

GO:0050501 hyaluronan synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.