Harbinger transposase-derived nuclease, animal (IPR026103)

Short name: HARBI1_animal

Overlapping homologous superfamilies


Family relationships



This entry represents the Harbinger transposase-derived proteins mostly from animals. Proteins in this family may have nuclease activity, but do not appear to have transposase activity [PMID: 15169610, PMID: 18339812].

Harbinger DNA transposons have been identified in protists, plants, insects, worms, and vertebrates. However, mammals do not have Harbinger transposons. In human, no recognisable members of Harbinger transposase superfamily are found. Instead, a widely expressed HARBI1 gene encoding a 350-amino acid protein derived from a Harbinger transposase has been identified [PMID: 15169610]. The HARBI1 protein is conserved in humans, rats, mice, cows, pigs, chickens, frogs and various bony fish [PMID: 15169610]. Conserved motifs, which are expected to be catalytic centres of nuclease/ligase reactions necessary for transpositions, found in the Harbinger transposases, are also well preserved in the HARBI1 proteins [PMID: 15169610]. It was also proposed that these hypothetical HARBI1 nucleases are also characterised by a strong DNA-target specificity [PMID: 15169610].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.