Activating transcription factor 7-interacting protein (IPR026085)

Short name: ATF7-int

Overlapping homologous superfamilies


Family relationships


Activating transcription factor 7-interacting protein (MCAF) family consists of MCAF1 and MCAF2 [PMID: 15691849].

MCAF1 (also known as MBD1-containing chromatin-associated factor 1) is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can both act as an activator or a repressor depending on the context [PMID: 10777215, PMID: 14536086].

MCAF2 might be involved in the transcription modulation during gonad development [PMID: 16850184].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.