Disrupted in schizophrenia 1 (IPR026081)

Short name: DISC1

Overlapping homologous superfamilies


Family relationships



Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family [PMID: 11443544, PMID: 10814723].

Human DISC1 is multifunctional with several interacting proteins, including components of the dynein motor protein complex, such as nuclear distribution element-like (NDEL1/NUDEL) and lissencephaly 1 protein (LIS1). DISC1 is also required for regulation of microtubule dynamics, neurite outgrowth and neuronal migration in vivo [PMID: 17035248].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.