Lck-interacting transmembrane adapter 1 (IPR026072)

Short name: Lime1

Overlapping homologous superfamilies


Family relationships



Lime is involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. It couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilisation or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules [PMID: 14610044, PMID: 16249387].

GO terms

Biological Process

GO:0050853 B cell receptor signaling pathway
GO:0050852 T cell receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.