Family

SIN3-HDAC complex-associated factor (IPR026065)

Short name: FAM60A

Family relationships

None.

Description

SIN3-HDAC complex-associated factor (also known as FAM60A) is found in eukaryotes. It has been shown to be a subunit of the Sin3 deacetylase complex (Sin3/HDAC), important for the repression of genes involved in the TGF-beta signaling pathway [PMID: 22984288],[PMID: 22865885].

Human FAM60A protein has been shown to be up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors. Human FAM60A is phosphorylated upon DNA damage, probably by ATM or ATR [PMID: 17525332].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER