PC-Esterase (IPR026057)

Short name: PC-Esterase

Overlapping homologous superfamilies


Family relationships


The PC-Esterase family [PMID: 20056006] is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1 [PMID: 20657172, PMID: 21408051], animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily [PMID: 20056006]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [PMID: 20056006, PMID: 21408051]. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity [PMID: 20056006]. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes [PMID: 20056006]. The plant family with PMR5, ESK1, TBL3 etc have an N-terminal C rich potential sugar binding domain followed by the PC-Esterase domain [PMID: 20056006].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.