DNA-binding protein inhibitor (IPR026052)

Short name: DNA-bd_prot-inh

Overlapping homologous superfamilies

Family relationships



Transcription factors containing basic-helix-loop-helix (bHLH) domains interact to regulate differentiation in a number of cellular systems, including myogenesis, neurogenesis and haematopoiesis [PMID: 8139914]. The DNA-binding activity of these proteins is mediated via the basic region of the bHLH domain, and is dependent upon formation of homo- and/or heterodimers by these transcription factors.

The Id family of proteins (whose members include Id1, Id2, Id3 and the Drosophila homologue emc) contain a HLH-dimerization domain but lack the DNA-binding basic region. Formation of heterodimers between these proteins and bHLH domain-containing transcription factors abolishes the DNA-binding ability of the latter, thus inhibiting their activity [PMID: 16556596].

GO terms

Biological Process

GO:0045892 negative regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.