Family

ATPase, V0 complex, subunit 116kDa, eukaryotic (IPR026028)

Short name: V-type_ATPase_116kDa_su_euka

Family relationships

Description

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.

There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [PMID: 15473999, PMID: 15078220]. The different types include:

  • F-ATPases (ATP synthases, F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).
  • V-ATPases (V1V0-ATPases), which are primarily found in eukaryotes and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane [PMID: 20450191]. They are also found in bacteria [PMID: 9741106].
  • A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [PMID: 18937357, PMID: 1385979].
  • P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.
  • E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.

This entry represent eukaryotic V-ATPase 116 kDa subunit (also known as subunit a). V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex [PMID: 1491220]. V-ATPase 116 kDa subunit is part of the integral membrane V0 complex of vacuolar ATPase and is essential for assembly and catalytic activity [PMID: 8798414]. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF