Anaphase-promoting complex subunit 5 domain (IPR026000)

Short name: Apc5_dom

Overlapping homologous superfamilies


Domain relationships



This entry represents a domain found in Apc5 (anaphase-promoting complex subunit 5).

Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multisubunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Tetratricopeptide repeat protein 19 is a mitochondrial protein required for formation of the mitochondrial complex III [PMID: 21278747].

Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [PMID: 15082755, PMID: 16896351]. The N terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC [PMID: 19584054]. This region of the Apc5 member proteins carries a TPR-like motif.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.