Domain

RNA binding activity-knot of a chromodomain (IPR025995)

Short name: Tudor-knot

Domain relationships

None.

Description

This is a novel knotted tudor domain which is required for binding to RNA. The knot influences the loop conformation of the helical turn Ht2 (residues 61-63) that is located at the side opposite the knot in the tudor domain-chromo domain; stabilisation of Ht2 is essential for RNA binding [PMID: 18407291].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam