Domain

DBC1/CARP1 catalytically inactive NUDIX hydrolase domain (IPR025954)

Short name: DBC1/CARP1_inactive_NUDIX_dom

Domain relationships

None.

Description

Deleted in breast cancer 1 (DBC1), also known as cell division cycle and apoptosis regulator protein 2 (CCAR2), and its paralogous cell division cycle and apoptosis regulator protein 1 (CCAR1) are large multi-domain proteins, with a nuclear or perinuclear localisation, and a role in promoting apoptosis upon processing by caspases [PMID: 18418069].

This entry represents the central conserved globular domain present in DBC1 and homologues, and is a catalytically inactive version of the Nudix hydrolase (MutT) domain [PMID: 18418069]. It may have a role in binding NAD metabolites, such as ADP-ribose.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART