Insulin-induced protein family (IPR025929)

Short name: INSIG_fam

Overlapping homologous superfamilies


Family relationships


This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations [PMID: 12202038,PMID: 12242332].

The INSIG family also includes NSG1 and NSG2 (INSIG homologues 1 and 2) [PMID: 16270032].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.