Domain

Phostensin/Taperin PP1-binding domain (IPR025907)

Short name: Phostensin/Taperin_PP1-bd_dom

Domain relationships

None.

Description

Phostensin has been identified as a PP1 regulatory protein, binding PP1 at the KISF motif found in this domain. This domain also appears to carry an incomplete SH3-binding domain PxRxP further upstream. It is likely that phostensin targets PP1 to the F-actin cytoskeleton [PMID: 17374523]. Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [PMID: 19622346].

This domain is also found in the taperin, which is a PP1 binding protein that is ancestrally related to phostensin. Taperin has a role in sound perception [PMID: 20170899].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019902 phosphatase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam