Domain

Major prion protein N-terminal domain (IPR025860)

Short name: Prion_N_dom

Domain relationships

None.

Description

This entry represents the N-terminal domain of major prion protein. The proteins consist of mainly alpha helices. Bovine prion has been shown to form a stable helix which inserts in a transmembrane location in the bilayer, with the N -terminal functioning as a cell-penetrating peptide [PMID: 15554701].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam