Thiopurine S-methyltransferase (IPR025835)

Short name: Thiopurine_S-MeTrfase

Overlapping homologous superfamilies

Family relationships


This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulphydryl compounds, including anticancer and immunosuppressive thiopurines [PMID: 9780226]. Thiopurine is commonly used to suppress the immune system in the case of autoimmune disease, inflammatory bowel disease and to prevent transplanted organ rejection [PMID: 16207256]. Thiopurine drugs can be toxic to cells but their effect can be mediated by the incorporation of thioguanine nucleotides into DNA [PMID: 15570193].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008119 thiopurine S-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.