Family

Fanconi anemia group F protein, metazoa (IPR025825)

Short name: FANCF_met

Family relationships

Description

Fanconi anemia (FA) is a genomic instability syndrome caused by mutations in at least 13 distinct genes whose products function in a common DNA repair signaling pathway, the FA pathway. The FA pathway cooperates with other DNA repair proteins for resolving DNA interstrand cross-links during replication [PMID: 20713514].

Fanconi anemia group F protein (FANCF) is a component of the FA core complex [PMID: 16357213, PMID: 17768402]. FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [PMID: 16418574].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0043240 Fanconi anaemia nuclear complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom