tRNA (uracil-5-)-methyltransferase, metazoa (IPR025823)

Short name: tRNA_(uracil-5-)_MeTrfase_met

Family relationships



This entry represents a family of tRNA (uracil-5-)-methyltransferase homologues (EC: found in metazoa. In Saccharomyces cerevisiae this enzyme catalyses the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA and may have a role in tRNA stabilisation or maturation [PMID: 10864043, PMID: 12003492].

Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [PMID: 16225687, PMID: 21858014, PMID: 12826405]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [PMID: 7897657]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [PMID: 16225687, PMID: 21858014, PMID: 7897657]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [PMID: 16225687, PMID: 21858014, PMID: 12826405]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles