Conserved Site

Methyltransferase NNMT/PNMT/TEMT, conserved site (IPR025820)

Short name: NNMT/PNMT/TEMT_CS

Description

Several cytoplasmic vertebrate methyltransferases are evolutionary related [PMID: 8182091], including nicotinamide N-methyltransferase (EC:2.1.1.1) (NNMT); phenylethanolamine N-methyltransferase (EC:2.1.1.28) (PNMT); and thioether S-methyltransferase (EC:2.1.1.96) (TEMT). NNMT catalyses the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds. PNMT catalyses the last step in catecholamine biosynthesis, the conversion of noradrenalin to adrenalin; and TEMT catalyses the methylation of dimethyl sulphide into trimethylsulphonium. These three enzymes use S-adenosyl-L-methionine as the methyl donor. They are proteins of 30 to 32 kDa.

This entry represents the most conserved region, a stretch of 16 residues which are located in the N-terminal section of these enzymes.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns