Domain

RrmJ-type ribose 2-O-methyltransferase domain (IPR025816)

Short name: RrmJ-type_MeTrfase

Domain relationships

Description

This domain is found in cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1, which is a S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs [PMID: 20713356]. It methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA to produce m7GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. It may be involved in the interferon response pathway [PMID: 18533109]. This group also includes A8XYX3, which is thought to be inactive as it lacks the conserved Lys active site in position 367.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles