tRNA methyltransferase 10 homologue C (IPR025812)

Short name: TRM10C

Overlapping homologous superfamilies

Family relationships


Mitochondrial RNase P (mtRNase P) cleaves tRNA molecules in their 5'-ends and consists of 3 components: a tRNA methyltransferase (MRPP1/TRMT10), a dehydrogenase/reductase-family member (MRPP2/HSD17B10), and MRPP3 (KIAA03910) [PMID: 18984158].

This entry represents tRNA methyltransferase 10 homologue C (TRMT10C), which is a metazoa homologue to yeast TRM10, a tRNA m1G methyltransferase responsible for modification at position 9. In humans there are three TRM10 orthologues. Mutations in TRMT10C cause mitochondrial disease [PMID: 27132592].

GO terms

Biological Process

GO:0008033 tRNA processing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.