Domain

Adrift-type ribose 2-O-methyltransferase domain (IPR025807)

Short name: Adrift-typ_MeTrfase

Domain relationships

Description

In higher eukaryotes, including insects, vertebrates and their viruses, mRNA and snRNA 5'-ends are modified by the addition of methyl groups to the first and/or the second transcribed nucleotides. Methylation of the ribose on the second transcribed position is termed cap2, and the enzyme responsible is the cap-specific mRNA (nucleoside-2'-O-)-methyltransferase or cap methyltransferase 2 [PMID: 21310715]. In Drosophila, this protein was originally known as adrift, and was isolated as a gene required for pathfinding on the segmental nerve [PMID: 10068643].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles