Histone H3-K79 methyltransferase (IPR025789)

Short name: Histone_H3-K79_MeTrfase

Family relationships


This family is also known as histone lysine methyltransferase DOT1. Members of this family methylate histone H3 to form H3K79me. In Saccharomyces cerevisiae, this methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones [PMID: 9755194, PMID: 11029058, PMID: 12097318, PMID: 12152067, PMID: 12574507, PMID: 15632126, PMID: 16166626, PMID: 15292170].

In Drosophila melanogaster, this enzyme is required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. It is also involved in telomeric silencing but do not in centric heterochromatin. It probably participates in pairing sensitivity [PMID: 15371351].

In contrast to other histone-lysine methyltransferases, members of this family do not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [PMID: 16225687, PMID: 21858014, PMID: 12826405]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [PMID: 7897657]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [PMID: 16225687, PMID: 21858014, PMID: 7897657]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [PMID: 16225687, PMID: 21858014, PMID: 12826405]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles