Domain

TRC8 N-terminal domain (IPR025754)

Short name: TRC8_N_dom

Domain relationships

None.

Description

This region is found at the N terminus of the TRC8 protein (Q8WU17). TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains and has been suggested to contain a sterol sensing domain [PMID: 9689122]. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG [PMID: 20068067].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam