High pH protein family (IPR025752)

Short name: HPH_family

Overlapping homologous superfamilies


Family relationships



This is a family of closely related high pH (HPH) proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions [PMID: 15189990]. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER [PMID: 21097665]. Cells with mutant Hph1 and Hph2 proteins reveal phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterised. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium.

GO terms

Biological Process

GO:0006950 response to stress

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005783 endoplasmic reticulum

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.