Cleavage stimulation factor subunit 2, hinge domain (IPR025742)

Short name: CSTF2_hinge

Overlapping homologous superfamilies


Domain relationships



The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localisation. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex [PMID: 19887456].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.