RHIM domain (IPR025735)

Short name: RHIM_dom

Overlapping homologous superfamilies


Domain relationships



RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins [PMID: 11734559]. The RHIM (RIP homotypic interaction motif) domain is involved in virus recognition. It is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI [PMID: 19590578].

The RHIM domain is also located at the C terminus of TIR-domain-containing adapter-inducing IFN-beta (TRIF). It is essential for TRIF-induced apoptosis, and has been shown to contribute to TRIF-induced NF-kappaB activation [PMID: 15814722].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.