Domain

Histone deacetylase complex subunit SAP30 zinc-finger (IPR025717)

Short name: SAP30_zn-finger

Domain relationships

None.

Description

SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two beta-strands and two alpha-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure reveals a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 Zn-finger motif indicate a strong preference for nucleic acid substrates. The zinc-finger of SAP30 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex [PMID: 19223330].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam