Mechanosensitive ion channel inner membrane domain 1 (IPR025692)

Short name: MscS_IM_dom1

Overlapping homologous superfamilies


Domain relationships



The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock [PMID: 12080120]. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains [PMID: 16079835], and this domain is one of the inner membrane domains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.