Domain

GYF domain 2 (IPR025640)

Short name: GYF_2

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. It contains an evolutionary conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF, the site of interaction with proline-rich peptides. Proteins containing this domain include RME-8 (Required for receptor-mediated endocytosis 8), a DNAJC13 protein. RME-8 was first identified as a protein that is required for endocytosis in Caenorhabditis elegans. It coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation [PMID: 24643499].

Proteins containing this domain also include Arabidopsis trithorax-related3 (Atxr3) and Tic56. Atxr3 is the major enzyme responsible for H3K4me3, which is critical for regulating gene expression and plant development [PMID: 20937886]. Tic56 is an essential subunit of a 1-MDa protein complex at the inner chloroplast envelope membrane [PMID: 28125316]. Tic56 also plays important roles in rRNA processing and chloroplast ribosome assembly [PMID: 27733515].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam