GYF domain 2 (IPR025640)

Short name: GYF_2

Overlapping homologous superfamilies


Domain relationships



This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. It contains an evolutionary conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF, the site of interaction with proline-rich peptides. Proteins containing this domain include RME-8 (Required for receptor-mediated endocytosis 8), a DNAJC13 protein. RME-8 was first identified as a protein that is required for endocytosis in Caenorhabditis elegans. It coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation [PMID: 24643499].

Proteins containing this domain also include Arabidopsis trithorax-related3 (Atxr3) and Tic56. Atxr3 is the major enzyme responsible for H3K4me3, which is critical for regulating gene expression and plant development [PMID: 20937886]. Tic56 is an essential subunit of a 1-MDa protein complex at the inner chloroplast envelope membrane [PMID: 28125316]. Tic56 also plays important roles in rRNA processing and chloroplast ribosome assembly [PMID: 27733515].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.