Growth arrest-specific protein 8 domain (IPR025593)

Short name: GAS8_dom

Overlapping homologous superfamilies


Domain relationships



This is the highly conserved central region of Gas8 proteins. Growth arrest-specific protein 8 (Gas8) is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localisation of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages [PMID: 11751847].

GO terms

Biological Process

GO:0048870 cell motility

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031514 motile cilium

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.