Repeat

HUWE1/Rev1, ubiquitin binding region (IPR025527)

Short name: HUWE1/Rev1_UBM

Description

This domain contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and REV1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM) [PMID: 26658142].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam