Domain

FIIND domain (IPR025307)

Short name: FIIND_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The function to find (FIIND) domain was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal) [PMID: 11408476]. NLRP1 is a member of the Nod-like receptor (NLR) protein superfamily and is involved in apoptosis and inflammation. To date, it is the only NLR protein known to have a FIIND domain. The FIIND domain is also present in the CARD8 protein where, like in NLRP1, it is followed by a C-terminal CARD domain. Both proteins are described to form an "inflammasome", a macro-molecular complex able to process caspase 1 and activate pro-IL1beta [PMID: 12563287]. The FIIND domain is present in only a very small subset of the kingdom of life, comprising primates, rodents (mouse, rat), carnivores (dog) and a few more, such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR) [PMID: 11076957]. Upon discovery of CARD8 it was noted that the N-terminal region shared significant sequence identity with an undescribed region in NLRP1 [PMID: 11408476]. Before getting its final name, FIIND [PMID: 12563287], this domain was termed NALP1-associated domain (NAD) [PMID: 12191486].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles